Product Name: Vitamin D3 (Cholecalciferol) Manufacturer: Shandong Kunda Biotechnology Co., Ltd Product Use: Nutritional supplement, food additive, feed additive Synonyms: Cholecalciferol, Vitamin D3 Chemical Formula: C27H44O CAS Number: 67-97-0 Contact Information: Kunda Industrial Park, Dezhou City, Shandong, China. Phone: +86-534-XXXXXXX
GHS Classification: Acute Toxicity – Oral (Category 4); Reproductive Toxicity (Category 2) Signal Word: Warning Hazard Statements: Harmful if swallowed. Suspected of damaging fertility or the unborn child. May cause skin or eye irritation in sensitive individuals. May affect calcium metabolism if ingested in excess. Pictograms: Exclamation mark; Health hazard Precautionary Statements: Do not handle without proper personal protection equipment. Avoid breathing dust. Wash hands after handling. Store in original, tightly closed packaging. In case of ingestion, seek medical advice immediately.
Ingredient: Cholecalciferol (Vitamin D3) Concentration: 98-100% (by weight) for pure product; concentration varies depending on formulation. Other Ingredients: May include inert excipients or carriers in premixes. Impurities: Not expected to be present at levels hazardous to health. Molecular Weight: 384.65 g/mol
Inhalation: Move person to fresh air. Provide oxygen if breathing is difficult. Seek medical attention for persistent symptoms. Skin Contact: Remove contaminated clothing and wash skin thoroughly with soap and water. Seek medical advice for irritation. Eye Contact: Rinse immediately with plenty of clean water for several minutes; remove contact lenses when possible. Get medical attention if irritation develops. Ingestion: Rinse mouth. Do not induce vomiting unless instructed by a medical professional. Seek immediate medical attention, especially if large amounts are swallowed. Notes for Physician: Symptomatic treatment as required. Monitor calcium levels in case of significant ingestion.
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray (do not use jet). Unsuitable Extinguishing Media: None known for this material. Fire Hazards: Substance may burn but does not ignite easily; forms hazardous fumes (carbon oxides) on combustion. Protective Equipment: Firefighters need full protective gear and self-contained breathing apparatus. Other Advice: Fight fire from upwind position. Cool containers exposed to heat with water spray.
Personal Precautions: Evacuate unnecessary personnel; avoid breathing dust; limit exposure through use of gloves, goggles, and dust mask. Environmental Precautions: Prevent spillage to drains and natural waterways. Cleaning Methods: Pick up spilled powder with non-sparking tools; keep in sealed container for disposal. Clean spill area with water and detergent to eliminate residue. Other Recommendations: Handle all waste according to local regulations.
Handling: Handle in well-ventilated area; minimize dust formation. Wash thoroughly after use. Do not eat, drink, or smoke while working. Storage: Store tightly closed in a cool, dry place, away from incompatible substances such as strong oxidizers and acids. Protect package from direct sun and moisture. Incompatibilities: Strong oxidizers, strong acids, strong bases. Packaging: Use light-resistant, sealed containers to avoid degradation.
Engineering Controls: Provide adequate ventilation, preferably local exhaust. Exposure Limits: No occupational exposure limits set for Cholecalciferol; exposure should be minimized. Respiratory Protection: Use NIOSH-approved dust masks when powder formation is possible. Eye Protection: Wear safety goggles or glasses with side shields. Skin Protection: Use chemical-resistant gloves; use long-sleeved clothing to avoid recurrent contact. Hygiene: Wash hands after working. Remove contaminated clothing and wash before reuse.
Appearance: White to off-white crystalline powder. Odor: Odorless or faint characteristic odor. Odor Threshold: Not available. pH: Not applicable (insoluble in water). Melting Point: 83 - 86°C Boiling Point: Decomposes before boiling. Flash Point: Not applicable. Evaporation Rate: Not applicable. Solubility: Insoluble in water; soluble in ethanol, fats, and oils. Partition Coefficient: log P (octanol/water): >7 (highly lipophilic). Vapor Pressure: Not available. Density: 0.8 - 1.0 g/cm³ (bulk) Decomposition Temperature: Above 150°C Viscosity: Not applicable.
Chemical Stability: Stable under recommended storage conditions. Sensitive to light, oxygen, and heat. Reactivity: Not reactive under normal use and conditions. Hazardous Reactions: No hazardous reactions expected with normal handling. Decomposition Products: Carbon monoxide, carbon dioxide, various hydrocarbons. Conditions to Avoid: Exposure to air, light, elevated temperatures. Incompatible Materials: Strong oxidizing agents, acids, bases.
Acute Toxicity: LD50 (oral, rat) ~42 mg/kg. Harmful if swallowed in large quantities; unlikely to cause symptoms in routine handling. Chronic Effects: Prolonged overexposure or misuse may lead to hypercalcemia, kidney stones, calcification of soft tissues. Routes of Exposure: Ingestion, inhalation of dust, skin or eye contact. Other Effects: Possible reproductive toxicity with high chronic exposures. Carcinogenicity: No ingredients listed as a carcinogen by IARC, NTP, OSHA. Skin/Eye Irritation: May cause mild irritation in sensitive individuals. Sensitization: Not expected to be a skin or respiratory sensitizer.
Persistence and Degradability: Readily biodegradable in soil and water; breakdown products are non-persistent. Bioaccumulation: High potential for bioaccumulation in aquatic organisms due to lipid solubility. Ecotoxicity: Toxic to aquatic organisms in high concentrations; avoid discharge to waterways. Low risk with regular industrial/professional use. Mobility in Soil: Limited; binds to organic matter. Other Adverse Effects: Not considered a significant environmental hazard under normal conditions of use.
Disposal Methods: Collect as non-hazardous pharmaceutical or chemical waste; incinerate or landfill according to local and national regulations. Container Handling: Empty containers may contain residue; triple rinse and dispose of with care. Special Precautions: Avoid direct release to environment; do not mix with municipal waste. Waste Code: Not specifically regulated as hazardous waste; user must determine proper classification.
UN Number: Not regulated for transport. Proper Shipping Name: Vitamin D3 (Cholecalciferol) Transport Hazard Class: Not classified as dangerous goods. Packing Group: None assigned. Marine Pollutant: No Special Precautions during Transport: Keep container tightly sealed. Protect from moisture, sunlight, and extreme temperatures.
Global Inventory Status: Listed in major chemical inventories (EU, US TSCA, China IECSC) Regulations: Subject to food additive or nutritional supplement regulations in many countries. Occupational health and safety regulations call for dust control and personal protection. Labeling Requirements: GHS label elements recommended. Other Provisions: Not regulated as a hazardous chemical for transport, but recommended precautions must be followed. Workplace Limits: No specific OELs, but general dust limits and safe handling standards apply. REACH Registration: Exempt due to natural occurrence and food additive use in Europe.
